I guess it depends what you mean by drafting. Are you talking Nascar at Talladega drafting or following 4-5 car lengths behind drafting?
I used to follow maybe 3 car lengths behind semi-trailers on the Interstate and it noticeably improved the fuel efficiency of various ICE vehicles. It also ruined my front bumper, hood, and windshield. I also know from an uncle who's a truck driver that it's a major stress for them. You can stop much faster than a loaded truck, but not if you're looking down at your radio or out the side window for a second.
More importantly, in recent years I've noticed how difficult it is to maintain a reasonable/safe following distance on the road. If I'm sitting 4-5 car lengths behind another car inevitably someone will swoop in between us (and blast the front of my car with road debris). If I back off to re-establish a decent following distance... here comes someone else to fill it up. One of the many reasons I no longer enjoy driving.