Yes, the major disadvantage is weight, and then the component count and complexity.
It is very inefficient, if you want to do a quick defrost or get a quick blast of air it takes lots considerable kw to heat the coil which heats water (cold or otherwise) and then it must be circulated by and electric pump and then it must all be heated to a temp high enough to warm all the cold parts in the system and the heat exchanger hot enough to then transmit the heat from a blowing fan. To make this process not take an unbearable time you must throw quite a bit of KW to speed it up. With resistive you get massive heat in about four seconds. It will defrost or warm you in an instant rather than minutes. If you just need to defrost with the radiant system it's like warming an entire car up, a waste of time and energy.
The major advantages of this "complex" heater system are:
1. There is a thermal mass that can be pre-heated.
This is a marginal benefit for most and it still wastes energy. It helps cold climate people a little but also has drawbacks for them.
2. The high voltage is not "exposed", so is safer if the car floods or people try to service the heater area. This "safety" issue might have been a BIG concern for Nissan.
This is not a safety issue, it is switched by a relay and there are plenty of HV lines in EVs, if you are under water you are under water and all is exposed. You can't get to the unit easily and it won't shock people.
3. The resistive heating can be a simple, energy-efficient ON/OFF, with no need to "regulate" the current to the resistor (which would waste energy). Yes, faster ON/OFF switching could be used, but perhaps Nissan wanted to avoid that "rapidly" fluctuating load on the main battery. Maybe they use a mechanical relay to turn it ON and OFF?
Marginal again, and the heat elements are self regulating due to the resistance increase when heat goes up, it works well when done properly, which is not difficult at all.
4. The thermal mass gives a more uniform heating effect.
You won't notice this on a proper system.